Transient response of basal ganglia network in healthy and low-dopamine state

Article history:

bioRxiv preprint doi: https://doi.org/10.1101/2021.01.05.425413; this version posted January 6,2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.

Kingshuk Chakravarty^1,†, Sangheeta Roy¹, Aniruddha Sinha¹, Atsushi Nambu^2,3, Satomi Chiken^2,3, Jeanette Hellgren Kotaleski^4,5, Arvind Kumar^4,†

AFFILIATIONS\\

¹TCS Research Innovation, Tata Consultancy Services, Kolkata, India

²Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, Japan.

³Department of Physiological Sciences, SOKENDAI (Graduate University for Advanced Studies), Okazaki, Japan

⁴Dept. of Computational Science和Technology, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden

⁵Dept. of Neuroscience, Karolinska Institute, Stockholm, Sweden

^†Corresponding author: [AK] arvkumar@kth.se, [KC] kingshuk.chakravarty@tcs.com

摘要

基底神经节(BG)对各种运动和认知功能至关重要。持续低多巴胺(如帕金森病)引起的变化，会导致稳态类活动($\beta-$波段振荡)的异常变化和BG的短暂响应。通常，短暂的皮质刺激会导致黑质网状部的三相响应(SNr, BG的输出)。三相响应的性质是由多巴胺水平决定的。虽然人们对BG的变化如何导致异常稳态活动已经有了相对较好的理解，但尚不清楚哪些BG相互作用对BG的异常瞬态响应至关重要。此外，尚不清楚稳态活动和瞬态响应异常变化的机制是相同的还是不同的。在这里，我们使用数值模拟BG的网络模型来确定决定瞬态响应形状的关键因素。我们发现，低多巴胺状态下的SNr异常瞬态响应，涉及到苍白球外段(GPe)的内部和GPe与丘脑下核(STN)之间的直接通路和反复交互作用的改变。我们发现，从D2型棘状投射神经元到GPe的连接对瞬时响应的形成是最关键的，通过将它们恢复到健康水平，我们可以在低多巴胺状态下恢复瞬时响应的形状。最后，我们表明，BG的变化导致异常的瞬态响应也足以产生病理振荡活动。

原文：Transient response of basal ganglia network in healthy and low-dopamine state

译文：健康和低多巴胺状态下基底神经节网络的瞬态响应